SHU is governed by its Board of Governors (BoG), which includes:

Dr. M S Habib Life Chairperson
Dr. Iram Afaq Chancellor
Prof. Dr. M. Shakeel Ahmed Khan Vice Chancellor
Mr. Justice Karim Khan Agha Member BoG
Dr. Syed Junaid Zaidi (NI, HI) Member BoG
Dr. Jonathan Addleton Member BoG
Mr. Fazlur Rehman Member BoG
Mr. Ali Naqvi Member BoG
Dr. A Q Mughal
Nominee, Higher Education Comission (HEC)
Member BoG
Mr. Alamuddin Bullo
Secretary, Universities & Boards Department, Government of Sindh
Member BoG
Engr. Prof. Dr. Madad Ali Shah
Nominee, Sindh Higher Education Comission (SHEC)
Member BoG
Mr. Tariq Amin Member BoG
Dr. Hasan Tharani Member BoG
Mr. Muhammad Abbas Member BoG
Dr. Muhammad Hussain Habib Member BoG
Member Provincial Assembly of Sindh Member BoG
Member Provincial Assembly of Sindh Member BoG